Arthritis Treated by Marijuana
Arthritis is a medical condition, one that affections millions of people in America and commonly involves both pain and inflammation of a person’s joints as well as restricting their motion.
There are two main forms of arthritis – rheumatoid arthritis and osteoarthritis. A person’s immune system might be a major cause of rheumatoid arthritis. When a person’s immune system is not working appropriately, instead of fighting off viruses or bacteria it may start targeting and attacking their entire body. Ultimately, the person’s bones start to become worn away or eroded.
Rheumatoid Arthtitis is common among baby boomers, those who are aging, and seniors. Arthritis is not; however, something strictly associated with age or aging – it has the potential to affect anyone despite their particular age.
Another form of arthritis is osteoarthritis, a condition that occurs when a person’s cartilage wears away. When this happens it has the potential to affect a person’s knees, hips, lower back, hands, or neck. At this time, there is no cure or remedy for osteoarthritis, although there are types of treatments available such as medical marijuana that have the potential to help reduce and relieve the pain associated with it.
Medical marijuana for use in relieving the pain associated with rheumatoid and osteoarthritis has been proven to be effective and successful in both women and men. The forms of arthritis are often times painful and distressful and medical marijuana appears to alleviate and relieve the chronic pain related to arthritis. Use of marijuana for medical reasons, particularly to relieve pain, seems to have been in use since the 1700’s and earlier around the world.
Medical marijuana has also demonstrated an ability to directly treat inflammatory diseases. Enough proof exists that medical marijuana has powerful anti-inflammatory and immune-modulation qualities. Included in the non-psychoactive elements of marijuana is, ‘cannabidiol,’ which has been found to restrain an immune reaction in both rats and mice that is similar to arthritis. Cannabidiol has been found to minimize destruction of the joints in rats and mice as well.
Scientific tests involving people have also proven that medical marijuana is successful in fighting arthritis. Stiffness, mobility, and range of motion have been proven to increase and reduce in those who use it. When using medical marijuana, people with forms of arthritis are actually able to use far less non-steroidal, anti-inflammatory medications that have the potential to be dangerous, harmful, and unsafe.
Another primary element of marijuana is, ‘THC.’ When a person’s body metabolizes THC it generates a certain amount of chemicals that include at least one that is an anti-inflammatory. THC also achieves relief from pain associated with arthritis.
Facts About Marijuana
A number of states are implementing medical marijuana laws and policies due to the increasing popularity of research into medical marijuana. At this time, several states have some type of medical marijuana law. In the recent election cycle, the state of Colorado for example, legalized recreational use of marijuana. On a federal level, marijuana possession remains illegal. States that approve and regulate medical marijuana include:
- New Jersey
- New Mexico
- Rhode Island
Medical marijuana has been proven to help with Rheumatoid and Osteoarthritis. Marijuana is a natural type of pain relief, unlike other products on the market. Marijuana does not contain pharmaceutical chemicals, for example.
Forms of Arthritis and Marijuana
Osteoarthritis also referred to as, degenerative arthritis,’ is a form of arthritis caused by the breakdown and eventual loss of a person’s cartilage in one or more of their joints. According to the National Academy of an Aging Society, arthritis is one of the most common chronic medical conditions in the United States of America. There are more than one hundred different forms of arthritis including osteoarthritis which is the most common form of arthritis. Osteoarthritis affects more than twenty million people in America alone.
The many forms of arthritis together cost people in America billions of dollars. In one example, a Stanford University study titled, ‘The Economic Impact of Arthritis,’ found that people with arthritis collectively spend over fifty-six billion dollars every year in both medical costs and due to loss of work. The financial costs alone related to arthritis are very high.
At this time, more than one hundred medications and drugs are used to treat forms of arthritis. Many people still prefer to treat arthritis pain with medical marijuana – something that is affordable, a natural alternative, and does not have the side effects found in the medications that are traditionally used to treat forms of arthritis. Scientific studies have demonstrated that medical marijuana can be an effective way to manage the symptoms of arthritis. The Journal of Neuroimmunology stated in an article titled, ‘Cannabinoids and the Immune System: Potential for the Treatment of Inflammatory Diseases” by J. Ludovic and Takashi Yamamura, that cannabinoids might be considered to treat inflammatory diseases like forms of arthritis.
In addition, Ethan Russo, M.D. the Senior Medical Advisor at the Cannabinoid Research Institute stated in an, ‘Americans for Safe Access,’ brochure titled, ‘Arthritis and Medical Marijuana” that science has demonstrated that the THC component of cannabis is a very effective analgesic, or pain killer. Ethan stated that the, ‘CBD,’ or cannabidiol component of marijuana has unique immunomodulatory benefits as an antagonist of tumor necrosis factor-alpha and has supporting benefits in relation to the treatment of rheumatoid arthritis.
Information : Medical Marijuana Treatments
The word arthritis means joint inflammation, however, we use the term arthritis to describe more than 100 rheumatic diseases. The major complaint by individuals who have arthritis is joint pain. Pain is often constant, and may be localized to the joint affected.
Recent years have brought a wealth of new scientific understanding regarding how medical marijuana or cannabis can be beneficial for treating Arthritis.
Types of arthritis include
- Osteoarthritis is the most common type of arthritis. It’s often related to aging or to an injury.
- Infectious arthritis is an infection that has spread from another part of the body to the joint.
- Psoriatic arthritis affects people with psoriasis.
- Gout is a painful type of arthritis that happens when too much uric acid builds up in the body. It often starts in the big toe.
RA is an inflammatory disease of the joints characterized by pain, stiffness, and swelling, as well as an eventual loss of limb function. Rheumatoid arthritis affects about one percent of the population, primarily women.
The use of cannabis to treat symptoms of RA is frequently self-reported by patients. In a 2005 anonymous questionnaire survey of medicinal cannabis patients in Australia, 25 percent reported using cannabinoids to treat RA. A survey of British medical cannabis patients found that more than 20 percent of respondents reported using cannabis for symptoms of arthritis. A review of state-registered medical cannabis pain patients reported that 27 percent used it to treat arthritis. Nevertheless, there exists limited clinical data with respect to the use of cannabinoids on RA in the literature at this time.
In January 2006, investigators at the British Royal National Hospital for Rheumatic Disease reported successful treatment of arthritis with cannabinoids in the first-ever controlled trial assessing the efficacy of natural cannabis extracts on RA. Investigators reported that the administration of cannabis extracts over a five week period produced statistically significant improvements in pain on movement, pain at rest, quality of sleep, inflammation and intensity of pain compared to placebo. No serious adverse effects were observed. Similar results had been reported in smaller trials investigating the use of orally administered cannabis extracts on symptoms of RA. A randomized, placebo-controlled trial assessing the use of vaporized cannabis in osteoarthritis patients began in Canada in 2016. Nonetheless, the limited number of studies and their short-term duration “allows for only limited conclusions for the effects of cannabinoids in rheumatic conditions.”
Preclinical data indicates that cannabinoids moderate RA progression. Writing in the Journal of the Proceedings of the National Academy of Sciences, investigators at London’s Kennedy Institute for Rheumatology reported that cannabidiol administration suppressed the progression of arthritis in vitro and in animals. Administration of CBD after the onset of clinical symptoms protected joints against severe damage and “effectively blocked [the] progression of arthritis,” investigators concluded. Daily administration of the synthetic cannabinoid agonist HU-320 has also been reported to protect joints from damage and to ameliorate arthritis in preclinical models, as has the administration of the cannabinoid agonist HU-444.
Summarizing the available literature in the Journal of Neuroimmunology, researchers at Tokyo’s National Institute for Neuroscience concluded, “Cannabinoid therapy of RA could provide symptomatic relief of joint pain and swelling as well as suppressing joint destruction and disease progression.” More recently, experts in the field have opined that “specific activation of CB2 (receptor) may relieve RA” and that “a selective CB(2) agonist could be a new therapy for RA.”
Post Traumatic Arthritis and Marijuana Information: Treat Arthritis With Cannabis!
The disorder defined as inflammation of a joint. The most common cause is wearing out of joint surface cartilage (osteoarthritis). Post-traumatic arthritis is caused by the wearing out of a joint or from any kind of physical injury.
The injury could be from sports, a vehicle accident, a fall, a military injury, or any other source of physical trauma.
Such injuries can damage the cartilage and/or the bone, changing the mechanics of the joint and making it wear out more quickly. The wearing-out process is accelerated by continued injury and excess body weight.
The symptoms of post-traumatic arthritis include joint pain, swelling, fluid accumulation in the joint, and decreased tolerance for walking, sports, stairs, and other activities that stress the joint.
Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid Arth..
- Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK. firstname.lastname@example.org
Cannabis-based medicines have a number of therapeutic indications, including anti-inflammatory and analgesic effects. The endocannabinoid receptor system, including the cannabinoid receptor 1 (CB1) and receptor 2 (CB2) and the endocannabinoids, are implicated in a wide range of physiological and pathophysiological processes. Pre-clinical and clinical studies have demonstrated that cannabis-based drugs have therapeutic potential in inflammatory diseases, including rheumatoid arthritis (RA) and multiple sclerosis. The aim of this study was to determine whether the key elements of the endocannabinoid signalling system, which produces immunosuppression and analgesia, are expressed in the synovia of patients with osteoarthritis (OA) or RA.
Thirty-two OA and 13 RA patients undergoing total knee arthroplasty were included in this study. Clinical staging was conducted from x-rays scored according to Kellgren-Lawrence and Larsen scales, and synovitis of synovial biopsies was graded. Endocannabinoid levels were quantified in synovial fluid by liquid chromatography-mass spectrometry. The expression of CB1 and CB2 protein and RNA in synovial biopsies was investigated. Functional activity of these receptors was determined with mitogen-activated protein kinase assays. To assess the impact of OA and RA on this receptor system, levels of endocannabinoids in the synovial fluid of patients and non-inflamed healthy volunteers were compared. The activity of fatty acid amide hydrolase (FAAH), the predominant catabolic endocannabinoid enzyme, was measured in synovium.
CB1 and CB2 protein and RNA were present in the synovia of OA and RA patients. Cannabinoid receptor stimulation of fibroblast-like cells from OA and RA patients produced a time-dependent phosphorylation of extracellular signal-regulated kinase (ERK)-1 and ERK-2 which was significantly blocked by the CB1 antagonist SR141716A. The endocannabinoids anandamide (AEA) and 2-arachidonyl glycerol (2-AG) were identified in the synovial fluid of OA and RA patients. However, neither AEA nor 2-AG was detected in synovial fluid from normal volunteers. FAAH was active in the synovia of OA and RA patients and was sensitive to inhibition by URB597 (3′-(aminocarbonyl) [1,1′-biphenyl]-3-yl)-cyclohexylcarbamate).
Our data predict that the cannabinoid receptor system present in the synovium may be an important therapeutic target for the treatment of pain and inflammation associated with OA and RA.
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